XDR (エックス・ディー・アール?) (short for "X-Dazedly-Ray") is a 1990 Japanese shoot 'em up game released for the Sega Mega Drive. It is a sideways scrolling shoot 'em up containing six levels.

X-Men is a home console video game produced by Sega in 1993, based on the adventures of the Marvel Comics superhero team, the X-Men. One or two players can play as any of four pre-chosen X-Men. X-Men is a Mega Drive/Genesis-exclusive game and in 1995 was followed up by X-Men 2: Clone Wars.

X-Men 2: Clone Wars is a 1995 platform game developed by Headgames and released by Sega of America for the Mega Drive/Genesis as a sequel to the 1993 side-scrolling video game X-Men. The game is based on the successful TV series from Marvel Comics. X-Men 2 was praised by critics and retrospectively acclaimed as one of the best games on the platform. It was supposed to be followed by a cancelled sequel titled X-Women.

X-Perts is a side-scrolling fighting action video game produced by Sega of America and released only in North America for the Sega Genesis in 1996. It is a spin-off of Eternal Champions starring the assassin Shadow Yamoto, who is depicted in her design from Eternal Champions: Challenge from the Dark Side.

Xenon 2 Megablast is a video game originally produced for the Amiga and Atari ST, and later converted to the PC, Sega Master System, Sega Mega Drive, Acorn Archimedes and Game Boy platforms. The sequel to Xenon was designed by Bitmap Brothers (although coded by The Assembly Line). It became one of their most well-known titles, and is a classic of its genre.

Exile is an action RPG video game series developed by Nihon Telenet. In Japan, the series is known as XZR and Exile in North America. The first game in the trilogy never saw a release outside of Japan. Exile had two different versions. The TurboGrafx CD version was released in English by Working Designs, and the Mega Drive / Genesis version was released in English by Renovation Products. Working Designs also were in charge of the English localization of the third game, Exile: Wicked Phenomenon. The Exile trilogy centers around Sadler, a Syrian Assassin, who is the main character of each game in the trilogy. The series is controversial and notorious for featuring various references to religious historical figures, modern political leaders, iconography, drugs, and time-traveling assassins.