Dune II: The Building of a Dynasty (retitled Dune II: Battle for Arrakis in Europe and Dune: The Battle for Arrakis for the Mega Drive/Genesis port respectively) is a Dune video game developed by Westwood Studios and released by Virgin Interactive on Jan 1, 1992. It is based upon David Lynch's 1984 movie Dune, an adaptation of Frank Herbert's science fiction novel of the same name.While not necessarily the first real-time strategy (RTS) game (elements of which previously appeared in Stonkers, The Ancient Art of War, Nether Earth, Command HQ, and particularly Herzog Zwei), Dune II established the format that would be followed for years to come.[1][2] As such, Dune II was the archetypal "real-time strategy" game. Striking a balance between complexity and innovation, it was a huge success and laid the foundation for Command & Conquer, Warcraft, StarCraft, and many other RTS games that followed.

Dynamite Duke (ダイナマイトデューク?) is a 1989 action arcade game developed by Seibu Kaihatsu. It was later ported to the Sega Master System, Sega Mega Drive and Sharp X68000. Being a Cabal-based shooter, it can be considered a follow-up to Seibu's Empire City: 1931 and Dead Angle.

Dynamite Headdy (ダイナマイト・ヘッディー, Dainamaito Heddī?) is a platformer video game developed by Treasure. It was released in 1994 by Sega for the Sega Mega Drive/Genesis, Sega Game Gear and Sega Master System. A port for the Sega 32X was planned, but was cancelled due to the system's low popularity. It was later released for the Wii's Virtual Console in July 2007 and has also been included as a part of Gunstar Heroes: Treasure Box Collection for PlayStation 2 and Sonic's Ultimate Genesis Collection for Xbox 360 and PlayStation 3.

Earth Defense (aka: The Earth Defend) is an unlicensed game for the Sega Mega Drive/Genesis; it was developed by AV Artisan and published by Realtec in both North America and Taiwan, without a license from Sega. The game cartridge and box shapes as well as quality in graphics and box art are identical to AV Artisan's previous titles Funny World & Balloon Boy and Whac-A-Critter, both published by Realtec. Earth Defense was also rare in that it was a simultaneous 2 player vertical scrolling shoot 'em up on the Genesis which primarily featured single player shoot 'em ups. The player takes on the role of a jet pilot assigned to liberate five world continents from a technologically advanced army.

Earthworm Jim is a run and gun platform video game featuring an earthworm named Jim in a robotic suit who battles evil. Created by Doug TenNapel and designed by David Perry, the game was developed by Shiny Entertainment and Playmates Interactive Entertainment. It was released for the Sega Genesis in 1994, and subsequently ported to a number of other video game consoles. The game was noted for its fluid, cartoon-like animation. It was well-received by critics, and received a sequel, Earthworm Jim 2, in 1995. Fifteen years later, Gameloft developed a high definition remake for the PlayStation Network and Xbox Live Arcade, titled Earthworm Jim HD, in 2010.

Ecco Jr. is a video game in the Ecco the Dolphin series, released in Summer 1995. It had the controls and basic gameplay of the other two Mega Drive/Genesis titles, but was very much geared towards younger players, lacking the high difficulty of Ecco the Dolphin and Ecco: The Tides of Time.

Ecco the Dolphin (title screen: Ecco) is an action-adventure game originally developed by Novotrade International for the Mega Drive, and published by Sega in 1992. The game's designer is Ed Annunziata. It is the first installment in the Ecco the Dolphin video game franchise. The player character, Ecco, is a bottlenose dolphin who travels through time to combat hostile extraterrestrials in Earth's oceans and on an alien spacecraft.