Super Thunder Blade (スーパーサンダーブレード?) is a shooter for the Sega Mega Drive/Genesis console, published by Sega. It was one of three launch titles for the console in Japan (the others being Space Harrier II and Altered Beast), as well as being one of the six launch titles for the console for its U.S. launch. It is a follow-up to the 1987 arcade game Thunder Blade. It was released for the Virtual Console on September 17, 2007. It was also included in the Sega Genesis Collection for PlayStation 2 and PlayStation Portable in 2007 and in Sonic's Ultimate Genesis Collection for Xbox 360 and PlayStation 3.

Superman (known in Europe as Superman: The Man of Steel) is the title of a video game released by Sunsoft for the Mega Drive/Genesis in 1992. It is based on the popular DC comic book characters of the same name and is a traditional single-player side-scrolling arcade game where the player controls Superman through various levels in an effort to defeat the evil supervillain named Brainiac. Other super villains, as bosses, include The Prankster, Metallo and Mr. Mxyzptlk. This game was planned to be released on the SNES, but was cancelled sometime before it was completed.

Sword of Sodan is a hack and slash video game released for the Amiga game system in 1989 by Discovery Software. In 1993 it was also released for the Apple Macintosh System 7 by Bethesda Softworks, and Electronic Arts released a scaled down port version for the Sega Genesis in 1990.

Sword of Vermilion (ヴァーミリオン, Vāmirion?, lit. "Vermilion") is a role-playing video game developed and published by Sega for the Mega Drive console in 1989. It was released in 1991 in North America and Europe. It was the first console-exclusive game designed by Yu Suzuki. The game is part of the Sega Genesis Collection for the PlayStation 2 and PlayStation Portable, and is available on the Wii's Virtual Console.

Valis: The Fantasm Soldier II (夢幻戦士 ヴァリスⅡ Mugen Senshi: Varisu Tsū?), which had a remake done with super deformed characters and released as SD Valis (SDヴァリス Esu Dī Varisu?) on the Japanese Mega Drive and Syd of Valis – a translation mistake as SD means super deformed – on the North American Sega Genesis, is the second title in the Mugen Senshi Valis video game series. Like its predecessor, it is an action platformer.

Sylvester and Tweety in Cagey Capers (known in most of Europe as Sylvester & Tweety in Cagey Capers and in France as Titi & Grosminet dans une aventure infernale) is a video game featuring the Looney Tunes characters Sylvester and Tweety. It was released for the Sega Mega Drive/Genesis console in 1993. It was the first video game to star Sylvester and Tweety.

Syndicate is an isometric real-time tactical game from Bullfrog Productions created in 1993. It is the first title in the Syndicate series. An expansion pack, Syndicate: American Revolt, a sequel, Syndicate Wars, and a reboot Syndicate have also been released. The original game and expansion pack were re-released together in 1996 as Syndicate Plus.