Dune II: The Building of a Dynasty (retitled Dune II: Battle for Arrakis in Europe and Dune: The Battle for Arrakis for the Mega Drive/Genesis port respectively) is a Dune video game developed by Westwood Studios and released by Virgin Interactive on Jan 1, 1992. It is based upon David Lynch's 1984 movie Dune, an adaptation of Frank Herbert's science fiction novel of the same name.While not necessarily the first real-time strategy (RTS) game (elements of which previously appeared in Stonkers, The Ancient Art of War, Nether Earth, Command HQ, and particularly Herzog Zwei), Dune II established the format that would be followed for years to come.[1][2] As such, Dune II was the archetypal "real-time strategy" game. Striking a balance between complexity and innovation, it was a huge success and laid the foundation for Command & Conquer, Warcraft, StarCraft, and many other RTS games that followed.

Dynamite Duke (ダイナマイトデューク?) is a 1989 action arcade game developed by Seibu Kaihatsu. It was later ported to the Sega Master System, Sega Mega Drive and Sharp X68000. Being a Cabal-based shooter, it can be considered a follow-up to Seibu's Empire City: 1931 and Dead Angle.

Dynamite Headdy (ダイナマイト・ヘッディー, Dainamaito Heddī?) is a platformer video game developed by Treasure. It was released in 1994 by Sega for the Sega Mega Drive/Genesis, Sega Game Gear and Sega Master System. A port for the Sega 32X was planned, but was cancelled due to the system's low popularity. It was later released for the Wii's Virtual Console in July 2007 and has also been included as a part of Gunstar Heroes: Treasure Box Collection for PlayStation 2 and Sonic's Ultimate Genesis Collection for Xbox 360 and PlayStation 3.

Earth Defense (aka: The Earth Defend) is an unlicensed game for the Sega Mega Drive/Genesis; it was developed by AV Artisan and published by Realtec in both North America and Taiwan, without a license from Sega. The game cartridge and box shapes as well as quality in graphics and box art are identical to AV Artisan's previous titles Funny World & Balloon Boy and Whac-A-Critter, both published by Realtec. Earth Defense was also rare in that it was a simultaneous 2 player vertical scrolling shoot 'em up on the Genesis which primarily featured single player shoot 'em ups. The player takes on the role of a jet pilot assigned to liberate five world continents from a technologically advanced army.

Ecco the Dolphin (title screen: Ecco) is an action-adventure game originally developed by Novotrade International for the Mega Drive, and published by Sega in 1992. The game's designer is Ed Annunziata. It is the first installment in the Ecco the Dolphin video game franchise. The player character, Ecco, is a bottlenose dolphin who travels through time to combat hostile extraterrestrials in Earth's oceans and on an alien spacecraft.

El Viento (エル・ヴィエント, Eru Viento?, derived from Spanish meaning "The Wind") is a 2D platform video game released by Wolf Team and published by Renovation Products for the Sega Mega Drive/Sega Genesis game console in 1991. It is the second in a trilogy of games, which include Earnest Evans and Anett Futatabi. The game possesses many references to H. P. Lovecraft's esteemed Cthulhu Mythos. As with many Wolf Team games, the music was composed by Motoi Sakuraba.

Elemental Master is a top down shoot 'em up video game developed by Tecno Soft for the Sega Mega Drive and released in 1990 in Japan, and in 1993 in North America by Renovation Products.