Aerobiz (エアーマネジメント 大空に賭ける?, "Air Management: Ōzora ni Kakeru") is a business simulation video game for the Super Nintendo, Sharp X68000 and Mega Drive/Genesis game consoles, released in 1992 by Koei. As CEO of a budding international airline, the player has a limited amount of time to expand their business to become the industry leader against three other airlines (either AI-controlled or human opponents). The player has an amount of control over how their airline develops, such as the name, investments, what routes to fly, plane purchases, and other various aspects, while at the mercy of world events such as politics (for instance, if the player runs his or her airline out of Moscow, he or she can initially only buy Soviet planes and will have a harder time negotiating with Western nations) and natural disasters. The player can also get the company involved in peripheral businesses such as hotels and shuttle services. Once Perestroika is initiated, then the Cold War restrictions no longer apply in the game. The sequel Aerobiz Supersonic was released in August 1994 for the SNES and Mega Drive/Genesis. The player is presented with a wider variety of options in nearly everything, but the game play is much the same. Another sequel known as Air Management '96 was released only in Japan for the Sega Saturn and PlayStation.

Aerobiz Supersonic, known as Air Management II: Kōkū Ō wo Mezase (エアーマネジメントII 航空王をめざせ?) in Japan, is a business simulation video game released by Koei in US-America in August 1994, available on the Super Nintendo and the Mega Drive/Genesis. It is a sequel to Koei's previous airline simulation game, Aerobiz.

Air Buster: Trouble Specialty Raid Unit a.k.a. Aero Blasters: Trouble Specialty Raid Unit is a 1990 horizontally scrolling shoot 'em up video game developed and published by Kaneko and licensed to Namco. The game was originally released in the arcades in 1990 and was subsequently released for the PC Engine/TurboGrafx-16 (as Aero Blasters) and Sega Mega Drive/Genesis (as Air Buster in North America) in 1990 and 1991 respectively.In Air Buster, the player controls a fighter jet also designed for space travel and shoots enemies, collects power-ups, and defeats bosses to advance levels. As a console game, Air Buster had the distinction of being two player simultaneous, which was rare among side scrolling shooters on home consoles at the time; all games in the Thunder Force, Gradius, and R-Type series were only 1 player on the home consoles.

Air Diver: F-119 Stealth Fighter Simulation (エアダイバー?) is a combat flight simulator video game released by Seismic (Asmik Ace Entertainment in Japan) in April 1990 for the Sega Genesis/Mega Drive console. It is notable as being one of the two first third party published titles for the console in North America. A follow-up, Super Air Diver was released exclusively for the Super Nintendo Entertainment System years later.

Aleste (アレスタ?) is a 1988 shoot 'em up video game developed by Compile for the Master System. It is a direct successor to Compile's earlier Zanac, featuring many of the themes and gameplay mechanics of that work.

Alien Soldier (エイリアンソルジャー?) is a side-scrolling run and gun video game developed by Treasure for the Sega Mega Drive. The game was released in Japan and Europe, but not physically in the US (one of the few to be released in this pattern), but it can be rather expensive due to its rarity in either region. The game was playable in America on the Sega Channel cable service and has been reissued for PlayStation 2 as part of the Sega Ages Treasure Box disc. The Sega Ages version, whose disc also includes Treasure's Gunstar Heroes and Dynamite Headdy, exceeds the Mega Drive's intrinsic sprite display limit, which eliminates slowdowns or missing graphics during busy scenes (e.g. boss fights with many explosions). Also, the player can select either the sprite-based pixelated graphics of the original game or a new mode that uses certain filters to produce a high-resolution look. The game was re-released again on the Nintendo Wii's Virtual Console download service in Japan on October 9, 2007, in Europe on November 2, 2007, and North America debut on November 5, 2007. The game is listed in Guinness World Records Gamers Edition 2010 under the category "Most boss battles in a run and gun game". The catchphrases seen on the title screen, "FOR MEGADRIVERS CUSTOM" and "VISUALSHOCK! SPEEDSHOCK! SOUNDSHOCK! NOW IS TIME TO THE 68000 HEART ON FIRE!", describe the game's technical prowess for the Mega Drive hardware, at the core of which is the Motorola 68000 CPU.

Alisia Dragoon (アリシア ドラグーン) is a 1992 platform game for the Sega Mega Drive/Genesis. It was developed by Game Arts, who also published the game in Japan. Aiding the software developer was animation studio Gainax, who was responsible for the game's art and story. The player controls Alisia, a young woman who is on a quest to avenge her father and save the world. She can fire lightning from her hands and summon four faithful beasts to aid her. The game was released in North America and Europe by Sega, who packaged the heroine as a rugged gladiator instead of the dainty-looking sorceress she originally was. Due to the lack of substantial market penetration by the Mega Drive of Japan and the lack of publicity for the game overseas, Alisia Dragoon did not make a big impact on the video game market, despite the critical acclaim it received. The game was one of the first in the industry to present a female character in a leading role.

Altered Beast (獣王記, Jūōki?, lit. "Beast King's Chronicle") is a 1988 beat 'em up arcade game developed and manufactured by Sega. The game is set in Ancient Greece, and follows a centurion who is resurrected by Zeus to rescue his daughter Athena, and to do so becomes able to turn into beasts such as the werewolf with the use of power-ups. After its initial arcade release, it was ported to several home video game consoles and home computers, including the Sega Mega Drive and Sega Genesis, for which it was a pack-in game. This ultimately led to the Sega Genesis being shipped with Sonic the Hedgehog instead. The primary designer was Makoto Uchida, also responsible for the creation of Golden Axe.