Alien Soldier (エイリアンソルジャー?) is a side-scrolling run and gun video game developed by Treasure for the Sega Mega Drive. The game was released in Japan and Europe, but not physically in the US (one of the few to be released in this pattern), but it can be rather expensive due to its rarity in either region. The game was playable in America on the Sega Channel cable service and has been reissued for PlayStation 2 as part of the Sega Ages Treasure Box disc. The Sega Ages version, whose disc also includes Treasure's Gunstar Heroes and Dynamite Headdy, exceeds the Mega Drive's intrinsic sprite display limit, which eliminates slowdowns or missing graphics during busy scenes (e.g. boss fights with many explosions). Also, the player can select either the sprite-based pixelated graphics of the original game or a new mode that uses certain filters to produce a high-resolution look. The game was re-released again on the Nintendo Wii's Virtual Console download service in Japan on October 9, 2007, in Europe on November 2, 2007, and North America debut on November 5, 2007. The game is listed in Guinness World Records Gamers Edition 2010 under the category "Most boss battles in a run and gun game". The catchphrases seen on the title screen, "FOR MEGADRIVERS CUSTOM" and "VISUALSHOCK! SPEEDSHOCK! SOUNDSHOCK! NOW IS TIME TO THE 68000 HEART ON FIRE!", describe the game's technical prowess for the Mega Drive hardware, at the core of which is the Motorola 68000 CPU.

Alien Storm (エイリアンストーム?) is a 1990 beat 'em up arcade game by Sega. It was later ported to the Sega Mega Drive/Genesis and Sega Master System. The Sega Mega Drive version was also released on Wii's Virtual Console in 2007. The game appeared in Sega Mega Drive Ultimate Collection for Xbox 360 and PlayStation 3.

American Gladiators is an American competition television program that aired weekly in syndication from September 1989 to May 1996. The series matched a cast of amateur athletes against each other, as well as against the show's own gladiators, in contests of strength and agility. The concept was created by Dan Carr and John C. Ferraro, who held the original competition at Erie Tech High School in Erie, Pennsylvania. They sold the show to The Samuel Goldwyn Company (later MGM) where the concept was enhanced and became American Gladiators. An effort in 2004 to launch a live American Gladiators show on the Las Vegas Strip became mired in a securities fraud prosecution. However, the television series was restarted in 2008. Episodes from the original series were played on ESPN Classic from 2007 to 2009. Several episodes are available for download on Apple's iTunes Service.

Amy Rose in Sonic the Hedgehog 2 (aka Amy in Sonic 2) is a character swap hack Sonic the Hedgehog 2 for the Sega Mega Drive/Genesis, with character Amy Rose as playable character in place of Sonic the Hedgehog. The game's sprites (modified from Sonic CD) use Amy's initial design prior to Sonic Adventure.The game was modified by Sonic Retro member E-122-Psi, with additional programming and coding by other members including MarkeyJester, MainMemory, FraGag, Selbi and Hayate.

The game is made on the same engine as the Angry Birds in Russia including the music, there are two tracks from Chip And Dale Rescue Rangers and Mario 3.

Animaniacs is a video game that is based on the hit animated series of the same name. Unlike regular platform games, the player usually runs from the enemies rather than fighting them. Characters include Yakko, Wakko, and Dot, Pinky and the Brain, most of the supporting cast, as well as Ralph, the Warner Brothers studio guard. Animaniacs was made into two games which bore no relation to each other in terms of gameplay, despite both being made by Konami. One was for the Super Nintendo Entertainment System and the other was for the Sega Mega Drive/Genesis and Game Boy. The SNES and Mega Drive/Genesis version were released in 1994, and the Game Boy version in 1995.